Is NHEJ a tumor suppressor or an aging suppressor?
نویسندگان
چکیده
منابع مشابه
SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
SIRT1 has been considered as a tumor promoter because of its increased expression in some types of cancers and its role in inactivating proteins that are involved in tumor suppression and DNA damage repair. However, recent studies demonstrated that SIRT1 levels are reduced in some other types of cancers, and that SIRT1 deficiency results in genetic instability and tumorigenesis, while overexpre...
متن کاملIs miR-29 an oncogene or tumor suppressor in CLL?
B-cell chronic lymphocytic leukemia (CLL), the most common leukemia in the Western world. CLL occurs in two forms, aggressive and indolent. Aggressive CLL is characterized by high ZAP-70 expression and unmutated IgH V(H); indolent CLL shows low ZAP-70 expression and mutated IgH V(H). We recently found that miR-29 is up-regulated in indolent human B-CLL, compared to aggressive B-CLL and normal C...
متن کاملIs PML a Tumor Suppressor?
The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then syst...
متن کاملAMPK: a contextual oncogene or tumor suppressor?
The AMP-activated protein kinase (AMPK) functions to monitor and maintain energy homeostasis at the cellular and organism level. AMPK was perceived historically primarily as a component of the LKB1/STK11 tumor suppressor (LKB1 mutations cause the Peutz-Jegher cancer predisposition syndrome) cascade upstream of the TSC1/2/mTOR pathway and thus likely to be a tumor suppressor. However, AMPK has r...
متن کاملIs 15-LOX-1 a tumor suppressor?
A number of enzymes in the cyclooxygenase and lipoxygenase pathways process fatty acids to generate a variety of bioactive lipids. Recent findings that link inflammation to carcinogenesis have started to reveal how these bioactive lipids function in cellular signaling pathways as lipid messengers that mediate responses to cellular injury through inflammatory processes (1). Downstream effects of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2008
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.7.9.5807